Tumor-associated tissue eosinophilia in preinvasive and invasive squamous cell carcinoma of cervix

Background: Differentiating between preinvasive and invasive squamous neoplasms of the cervix can be a challenge in small, superficial fragments cervical biopsy, particularly when inflammatory infiltrates obscure epithelial stroma interface due to tangential sectioning acanthotic epithelium. This study evaluates whether thresholds eosinophils serve as morphological marker for presence tumor invasion cervix. Material methods: Sixty-five cases cell carcinoma neoplasia were evaluated. In each case, number per HPF 10 tissue adjacent neoplastic epithelium was counted. For statistical purposes, elevated categorized > 3 eosinophils/HPF, 5 >10/10 HPF. Results: Stromal present 1/5 LSIL, 3/8 HSIL cases, 15/16 microinvasive carcinoma, 34/36 signifying an increase eosinophil count from spectrum carcinoma. Greater than eosinophils/HPF >10 eosinophils/10 had sensitivity, specificity, positive predictive values 55%, 100%, 75%, 100%and respectively. The difference >5eosinophils/HPF >10eosinophils/10 SIL SCC statistically significant. Conclusions: Our suggests that increased associated with should prompt thorough evaluation evidence is absent.